FDA Warns That Anti-Seizure Drug Potiga Can Cause Skin, Eye Pigmentation Changes

The Food and Drug Administration April 26 warned the public that the anti-seizure medication Potiga (ezogabine) can cause blue skin discoloration and eye abnormalities characterized by pigment changes in the retina.

Potiga was approved by FDA in June 2011 for use as an add-on medication to treat seizures associated with epilepsy in adults (9 PLIR 754, 6/17/11). The drug was developed by Valeant Pharmaceuticals North America, of Durham, N.C., and is distributed by United Kingdom-based GlaxoSmithKline Plc.

FDA said it is working with the manufacturer to gather and evaluate all available information to better understand these events. The ...