FDA Warns Against Use of Xyrem With Alcohol, CNS Depressant Drugs

The Food and Drug Administration Dec. 17 said it is reminding health care professionals and patients that using Xyrem (sodium oxybate) with alcohol or central nervous system (CNS) depressant drugs can impair consciousness and lead to severe breathing problems.

Xyrem, which is made by Irish company Jazz Pharmaceuticals, is approved to reduce attacks of muscle weakness and to treat daytime sleepiness in patients with narcolepsy.

FDA said it has added a new contraindication to Xyrem’s label regarding alcohol. The label already contraindicates the drug’s use with insomnia drugs. Also, the agency said using Xyrem with other CNS depressant drugs such ...