Challenged claims of Personalis Inc.'s patent that describes systems and methods for sample processing and data analysis are unpatentable as anticipated by and obvious over prior art, the Patent Trial and Appeal Board said, in an inter partes review by Foresight Diagnostics Inc. The board determined that the challenged claims are anticipated by and obvious over prior art that employs tagged-amplicon deep sequencing for the detection and monitoring of cancer-associated alleles circulating in patient plasma samples, discloses a targeted, massively parallel sequencing approach to detect tumor genomic alterations, and discloses shotgun massively parallel sequencing of plasma DNA from cancer patients ...
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