Alnylam’s CEO Is Ready to Take Over From a Biotech Legend (1)

Yvonne Greenstreet was sitting on a plane at Boston Logan International Airport waiting to take off in 2018 when U.S. regulators approved Alnylam Pharmaceuticals Inc.’s first drug, Onpattro. The chief operating officer grabbed her carry-on from the overhead bin, ran off the plane and bolted to the office so she could celebrate the accomplishment with her colleagues.

Now Greenstreet will be leading many of those same colleagues as Alnylam’s new chief executive officer, and she has a tough task ahead of her. On Jan. 1 she took the reins from John Maraganore, who led Alnylam since its 2002 inception ...