Booster shots of
Additional doses of the two-shot messenger RNA vaccine should be offered to people 65 and older, along with adults 18 and older who are at high risk for medical or occupational reasons, the
The booster, which is half the original dose, should be given at least six months after the initial inoculation, the panel said.
Moderna shares gained as much as 4.9% in Thursday afternoon trading in New York.
The vote follows a similar recommendation from the panel on a booster from
Panel members agreed that the data Moderna presented to support the booster was thin, particularly the safety data for the half-dose booster. But they ultimately decided that it was good enough in the face of a continuing pandemic, amid signs that at least some at-risk people could develop serious breakthrough cases.
On safety, the experts were reassured by the fact that many people with weak immune systems have already gotten a full third dose of the Moderna shot with no apparent problems so far.
“These are extraordinary times, and we have to work with imperfect data,” said Eric Rubin, a panel member at the Harvard T.H. Chan School of Public Health, summing up the opinion of many panelists.
The FDA will now decide whether or not to grant a clearance. The agency doesn’t have to follow the advisory panel’s preferences, and can make its own determination about whether to authorize the booster and for what populations.
Once the FDA acts, the baton will be passed to the Centers for Disease Control and Prevention’s separate advisory group.
The CDC’s Advisory Committee on Immunization Practices is scheduled to meet on Oct. 20 and 21. The panel will make its own recommendations on boosters, and share that language with CDC Director Rochelle Walensky, who will then decide whether to adopt it or shape her own recommendations.
The FDA’s advisory committee will continue meeting Friday, when it considers booster shots from the third company with an authorized Covid vaccine, Johnson & Johnson. The single-shot J&J vaccine has had far less use than Moderna and Pfizer-BioNTech.
The end of the meeting will feature a discussion on mixing and matching boosters with different shots used in initial immunizations.
Pairing Covid immunizations with a different booster produces as much or more antibodies as boosting with the same shot, according to preliminary results from a U.S. government-sponsored trial released Wednesday.
(Updates with additional context and detail throughout)
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